Knoxville, TN (PressExposure) July 22, 2009 -- One of the most widely used drug in alcohol detoxification today is chlordiazepoxide, a drug closely associated with benzodiazepines. It is known to possess a medium to long half life but its active metabolite has a very long half life. Chlordiazepoxide has amnestic, anxiolytic, hypnotic and skeletal muscle relaxant properties which is why it's also used as medication to treat anxiety, tension, and motor excitements. The success of chlordiazepoxide in alcoholism detoxification was first found out in when 42 hospital patients admitted for acute and chronic alcoholism, and various psychoses and neuroses were treated with chlordiazepoxide. Though effective, chlordiazepoxide has also been known to induce tolerance that leads to dependence.
Chronic use of benzodiazepines, such as chlordiazepoxide leads to the development of tolerance with a decrease in number of benzodiazepine binding sites in mouse forebrain. According to several reviews, along with those made by adolescent drug rehab specialist, long term use of benzodiazepines were beneficial in the treatment of insomnia due to the development of tolerance. Benzodiazepines tended to lose their sleep promoting properties within 3â14 days of continuous use and in the treatment of anxiety the committee found that there was little convincing evidence that benzodiazepines retained efficacy in the treatment of anxiety after 4 months continuous use due to the development of tolerance.
Through tolerance, people would usually develop dependence on the drug, may it be physical, psychological, or even both. Chlordiazepoxide can cause physical dependence, addiction and what is known as the benzodiazepine withdrawal syndrome. According to adolescent drug rehab specialists, withdrawal from chlordiazepoxide or other benzodiazepines often leads to withdrawal symptoms which are similar to those seen with alcohol and barbiturates. The higher the dose and the longer the drug is taken the greater the risk of experiencing unpleasant withdrawal symptoms.
Though overdose rarely happens with benzodiazepines such as with chlordiazepoxide, there are still cases in which people would experience overdose with the drug. Chlordiazepoxide is a drug which is very frequently involved in drug intoxication, including overdose. According to adolescent drug rehab specialists, chlordiazepoxide overdose is considered a medical emergency and generally requires the immediate attention of medical personnel. The antidote for an overdose of chlordiazepoxide (or any other benzodiazepine) is flumazenil (Anexate).