Cambridge, United Kingdom (PressExposure) April 12, 2008 -- In 1946 amino acid analysis took months to provide results. By 1950 analysis times dropped to weeks. Then in 1958 Stanford Moore and William Stein made a major breakthrough and automated the amino acid analysis technique for the first time to enable the analysis to be completed in a single day.
50 years on, although the underlying principles of amino acid analysis remain the same, analysis times for full profiles now take less than two hours to perform. To analyse certain families of amino acids can take as little as 10 minutes. The accuracy of the gold standard amino acid analysis technique means that it remains the choice of thousands of laboratories worldwide.
âModern automated amino acid analysers are now compact bench top units with âload and goâ operation, optimised for convenience and performance. Although these days there are several methods used for the determination of amino acids there remains only one gold standard technique that provides accurate data suitable for diagnosis or exact determinations. The Biochrom 30 is the Gold Standard System for Gold Standard applications,â explained Sally Bee, Biochromâs Amino Acid Analysis Marketing Manager.
Biochrom has been the leading manufacturer of amino acid analysers for over 30 years with a large installed base of instruments. The companyâs continued product development over the decades has improved the speed of data output, increased sensitivity and minimised operator times for its new generation of automated amino acid analysers.
Dedicated amino acid analysis is the gold standard technique for the separation of amino acids. The technique is based on ion exchange liquid chromatography with ninhydrin detection and is used in a wide range of applications areas.
The Gold Standard Biochrom 30 Amino Acid Analyser comprises the instrument, a 84 position cooled autosampler, an analytical column with top-up resin, a prewash column, operating software, EZchrom Elite data manipulation software, a chemical kit with calibration standard, ninhydrin and buffer bottles, instruction manuals, a tool kit and spare parts/consumables kit. The system comes complete with a Pentium PC and Deskjet printer. Visit http://www.biochrom.co.uk for more information.
The original amino acid analyser opened up a new field for research by permitting the composition of proteins to be determined. The amino acid analyser paved the way for the rapid expansion of biochemistry. Stanford Moore and William Stein were awarded the Nobel Prize in 1972 for their contribution to biochemical analysis.
The eminent scientists devoted a lot of their research careers to developing techniques for the separation of amino acids. In 1958, together with DH Spackman, Moore and Stein published a description of an automated instrument for the separation and quantitative determination of ninhydrin-positive compounds. From that day automated amino acid analysis has become a key biochemical analysis technique used by thousands of scientists worldwide.