Monrovia, CA (PressExposure) January 27, 2014 -- Michiya Matsusaki, Assistant Professor at Osaka University, will speak about "Construction of Vascularized 3D Human Tissue Models and Their Applications for Drug Screening" at the Tissue Models & Drug Screening Conference, taking place May 6-7, 2014 in Berlin.
Developing artificial three-dimensional (3D) human tissues containing blood and lymph capillary networks is one of the key challenges in tissue engineering, and modulating 3D cell-cell interaction inside the 3D artificial tissues is a particularly significant issue. Dr. Matsusaki will share how his lab developed simple and unique bottom-up approaches using nanometer-sized, layer-by-layer films consisting of fibronectin and gelatin (FN-G) as a nanometer-sized extracellular matrix. The FN-G nanofilms were prepared directly on the cell surface and acted as a stable adhesive surface for interaction with the neighbor cells. This approach easily provided approximately 10 to 20 layered tissues and fully vascularized tissues, after only one day of incubation, and a sandwich culture of the endothelial cells obtained a width of over one centimeter.
When the lab used lymph endothelial cells together with blood endothelial cells, the individual capillary networks of blood and lymph capillaries were successfully obtained. Moreover, perfusable vascular networks, which have an opening pore at the surfaces, were constructed by controlling the cell location. Various molecules, nanoparticles, and blood cells were able to be injected into both the blood and lymph capillaries. These vascularized 3D tissues will be useful as an artificial human tissue model for tissue engineering and pharmaceutical applications.
Michiya Matsusaki received his Ph.D. degree in 2003 under the direction of Prof. Mitsuru Akashi from Kagoshima University, Japan. In 2005, he joined the Department of Applied Chemistry in the Graduate School of Engineering at Osaka University as a designated assistant professor. Since 2006, he has been an assistant professor of the department, where his research focus is on functional polymers and biomaterials for biomedical and tissue engineering applications.
For more information about the conference, please visit http://www.gtcbio.com/tissuemodels.