Cambridge, Cambridge United Kingdom (PressExposure) August 16, 2011 -- Novus Biologicals, an international supplier of antibodies and antibody-related products to bioscience researchers, has announced a new mouse monoclonal ABCG8 antibody.
ABCG8 is an ATP binding cassette family member which acts to exclude non-cholesterol sterol entry to the intestine, to promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. Novus' new ABCG8 antibody (Catalog Number NBP1-71706) is useful for highly specific Westerm blot, immunoprecipitation, and immunofluorescence staining on paraffin-embedded mouse samples.
Normal digestion is partially facilitated by the function of ABCG8 and its counterpart ABCG5, which together form a heterodimer which transports cholesterol out of the liver and into bile. Subsequently, cholesterol is eliminated from the bodies of healthy individuals. However, in cases of insulin resistance, this functionality is impaired, and digestion does not result in complete elimination of harmful cholesterol. Unsurprisingly, mutations in ABCG8 can lead to gallstone disease, biliary cancer, hypercholesterolemia and atherosclerosis. In studies related to diabetes, heart disease, and digestive cancers, ABCG8 is commonly assessed for normal expression, function and interaction with ABCG5.
The ABCG8 antibodies are highly characterized and extremely useful tools for cholesterol and lipid metabolism research. We also offer ABCG8 RNAi and various tissue slides and lysates for use as controls.