Hyderabad, Andhra Pradesh India (PressExposure) November 16, 2011 -- RI Technologies' (www.researchimpact.com) market insight report on Unnatural Amino Acids gives an insight into the different types of Unnatural Amino Acids (β-Amino Acids, β-Amino Acid Derivatives, Cyclic Amino Acids & Derivatives, D-Amino Acids, D-Amino Acid Derivatives, DL-Amino Acids, DL-Amino Acid Derivatives, L-Amino Acid Derivatives and Other ) and their application areas such as R&D, Pharmaceutical, Food & Feed, Agrochemicals and Other. The study includes estimations and predictions for 2005-2015 for the global Unnatural Amino Acids market by type and applications. Regional Analysis is covered separately for North America (United States and Canada); Europe (UK, Germany, Switzerland, Italy, The Netherlands, and Rest of Europe); Asia Pacific (China, Japan, India, South Korea, Australia, and Rest of Asia Pacific); and Rest of World. The text is complemented with graphical representations of 143 exhibits. Business profiles of 64 major companies are discussed in the report. The report serves as a guide to global Unnatural Amino Acids industry covering more than 570 companies that are engaged in Unnatural Amino Acids R&D, synthesis, discovery, testing and supply of derivatives, products and services. Information related to industrial activity, corporate developments, research trends, product releases, product developments, partnerships, collaborations, and mergers and acquisitions is also covered in the report.
Modern drug discovery research is increasingly experimenting with unnatural amino acids, the non-proteinogenic amino acids, either natural or chemically synthesized. Their unlimited structural diversity and versatile applications are being used as chiral building blocks and molecular scaffolds in building combinatorial libraries. These molecules are powerful ingredients in therapeutic peptidomimetics and are used as molecular probes which can assimilate the biological systems better. They show improved in vivo stability, better potency, oral absorption, tissue distribution, and better and selective responses. Unnatural amino acids are increasingly being used to alter the peptide's tertiary structure. Drug candidates with side chain modifications meet and match their biological targets. The pharmaceutical industry accounts for almost 80% of chiral market revenues. Despite the fact that chiral drugs have been in use much before the arrival of modern medicine, it is only now that chiral drugs in the pharmaceutical industry has gained so much attention. This is largely due to the understanding that enantiomers often show different bioactivity and metabolic fates. In addition there is also a commercial reason where pharmaceutical companies have the chance to extend patent coverage after expiry of patents on racemic drugs. This can take place through the development of the chiral switch enantiomers with suitable bioactivity.
In principle, an unnatural amino acid can be produced by procedures such as replacement of hydrogen by fluorine in a ring structure, or phenyl by another resonant ring system, or one kind of heterocyclic ring by another one, or a remnant from the framework of an amino acid by another remnant of one that is analogous in shape and size. Practically all the advantageous amino acid analogues have earlier existed as close structural isomers of amino acids that occur naturally. So far, no efficient analogs of proline, glutamic acid, aspartic acid, alanine, threonine, cysteine, serine or glycine have been accounted for. Probably, the biological sites that are involved in these amino acids are governed by particular size and shape of molecule when compared to amino acids of larger size. Some of the alterations that are performed for the production of anti-metabolites from the larger sized amino acids are not tenable with smaller sized amino acids. This is because the resultant compounds lack appreciable stability as in the case of fluoroglycine or substitution of sulfur for -CH2 within the molecular framework of glutamic acid or threonine. In this regard, the non-existence of proline analog is intriguing, though the occurrence of azetidine-2-carboxylic acid is worth mentioning. Most of the amino acid analogues could be conceived as anti-tumor, antiviral or antimicrobial. The amino acid analogues are regularly subjected to screening to find the possibility of anti metabolite activity to counteract bacteria. These experiments are all documented in detail and are useful for those who want to study the effect of analogues on proliferating bacteria. Unnatural Amino Acids market is a rapidly growing market in the intermediates sector. Majority of the products utilizing these compounds are pharmaceutical intermediates (β-Lactam Antibiotics).
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