Nagercoil, Tamilnadu India (PressExposure) April 28, 2011 -- Prenatal Paternity DNA Test
Below is our prenatal testing services.
If you have any questions about the testing process, please feel free to contact a confidential case counselor at 09360036111 (24 hours). We understand the sensitivities involved in this type of testing and will work with you to find the testing process that's right for you. As always, everything is strictly confidential.
Fetal Cell Prenatal Tests
Our fetal cell prenatal tests use the fetal cells found in the mother's blood to test for its paternity.
How They Work
Our fetal cell prenatal paternity tests use both fetal cells and fetal DNA isolation from maternal blood. During pregnancy, a variety of cell types of fetal origin, as well as fetal DNA, cross the placenta and circulate within maternal peripheral blood. This fetal material is a source of information about the genetic makeup of the developing fetus. Fetal genetic material can be detected in maternal blood early in gestation.
The rarity of fetal nucleated cells in maternal blood has made their isolation particularly challenging. To obtain quantities sufficient for analysis, the use of enrichment techniques is required. The investigators begin with a 30 ml maternal venous blood sample.
An initial enrichment step facilitates removal of many maternal non-nucleated cells through density gradient centrifugation. Subsequent "purification" of fetal cells is performed by:
1. Efficient magnetic cell separation technology and;
2. Cultivation of fetal progenitor cells.
The detection of fetal cells in maternal plasma is much simpler and more robust than the detection of fetal nucleated cells in maternal blood, and does not require prior enrichment. In fact, the concentration of fetal DNA in maternal plasma expressed as a percentage of total DNA has been measured from 0.39% (the lowest concentration measured in early pregnancy), to as high as 11.4% (in late pregnancy).
This approach has been shown to have application in the prenatal diagnosis of fetal rhesus D status, sex-linked disorders, fetal sex determination, and paternally inherited genotyping. In addition to maternal plasma, fetal DNA can also be detected in maternal urine; however, the sensitivity of detection is lower.
Advanced Health Care Inc,
I St Floor Smm Bldg, Next To Canara Bank,
K. P. Road, Nagercoil - 629 001
Kaniyakumari Dist, Tamil Nadu, India
Ph.No: 04652 - 295749 / 229749
Fax No: 04652 - 278248